Selective RNAVersus DNA G-Quadruplex Targeting by In Situ Click Chemistry**
نویسندگان
چکیده
It all clicks into place: A potent telomere-targeting small molecule has been identified by using the copper-free 1,3-dipolar cycloaddition of a series of alkyne and azide building blocks catalyzed by a non-Watson-Crick DNA secondary structure (see picture). This method rapidly identifies, otherwise unanticipated, potent small-molecule probes to selectively target a given RNA or DNA.
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عنوان ژورنال:
دوره 51 شماره
صفحات -
تاریخ انتشار 2012